加载中…
Recombinant Biotinylated Cynomolgus CD98 Protein is expressed in HEK293 cells with a His tag tag and Avi tag at the N-terminus. It contains amino acid residues Arg175-Ala599 (accession: XP_045227941.1).
The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells.
