Anti-CD30 Antibody (Brentuximab Biosimilar)

Name: Anti-CD30 Antibody (Brentuximab Biosimilar)
Brand: Puweituo Bio
SKU: CD30-AB001

Catalog numberCD30-AB001

HumanHEK293Molecular weight · 49.1 kDa

Product introduction

Anti-CD30 Antibody (Brentuximab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CD30, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.1 kDa and 23.7 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Brentuximab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Brentuximab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CD30, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Brentuximab Biosimilar with the EC50 of 2.8ng/ml determined by ELISA. (QC Test)

Background

The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions. CD30 expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs).

References

1.Oflazoglu E, Grewal IS, Gerber H. Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases. Adv Exp Med Biol. 2009;647:174-85. doi: 10.1007/978-0-387-89520-8_12. PMID: 19760074.

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Anti-CD30 Antibody (Brentuximab Biosimilar)

Catalog numberCD30-AB001

HumanHEK293Molecular weight · 49.1 kDa

Anti-CD30 Antibody (Brentuximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-CD30 Antibody (Brentuximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References