Human CCR2b VLP Protein

Name: Human CCR2b VLP Protein
Brand: Puweituo Bio
SKU: CCR2-HP001

Catalog numberCCR2-HP001

HumanHEK293Molecule · C-C CKR-2Molecular weight · 42.9 kDa

Product introduction

Human CCR2b VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains the indicated native protein sequence.

Product details

Molecular aliases: C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2
Protein length: Met1-Leu360
Expression system: HEK293
Molecular weight: 42.9 kDa
Purity: >95% (HPLC)
Endotoxin: <1 EU/μg (LAL assay)
Formulation: 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4. A water-soluble adjuvant is recommended for immunization applications.
Storage: Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
Negative control: VLP-HM00C

Background

The chemokine receptor CCR2B is an isoform of the receptor for CCL2, a major monocyte chemoattractant involved in inflammatory signaling. Filamin A associates with the CCR2B C-terminal region and contributes to receptor internalization and membrane localization.

References

1.Minsaas L, Planagumà J, Madziva M, et al. Filamin A binds to CCR2B and regulates its internalization. PLoS One. 2010;5(8):e12212. doi:10.1371/journal.pone.0012212. PMID: 20808917.

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