Mouse CCL24 Protein

Name: Mouse CCL24 Protein
Brand: Puweituo Bio
SKU: CCL24-MP001

Catalog numberCCL24-MP001

MouseHEK293Molecule · CK-beta-6Molecular weight · 11.7 kDa

Product introduction

Recombinant Mouse CCL24 Protein is expressed in HEK293 cells with a His tag at the N-terminus. It contains amino acid residues Val27-Val119 (UniProt accession: Q9JKC0).

Product details

Molecular aliases: CK-beta-6; Eotaxin-2; MPIF-2; MPIF2; SCYA24; Ckb-6; CCL24; member 24; CK-β-6; Ckb6; CK-b-6; CK-b6
Protein length: Val27-Val119
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 11.7 kDa. Due to glycosylation, the protein migrates to 20-28 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Lyophilized from 0.22 μm filtered solution in 20mM Tris, 500mM NaCl (pH 7.5). Normally 8% mannitol is added as protectant before lyophilization.
State: Lyophilized
Storage: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Reconstitution: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

Data display

Bis-Tris PAGE Data — Mouse CCL24 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Mouse CCL24 is greater than 90% as determined by SEC-HPLC.

Background

C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver.

References

1.Segal-Salto M, Barashi N, Katav A, Edelshtein V, Aharon A, Hashmueli S, George J, Maor Y, Pinzani M, Haberman D, Hall A, Friedman S, Mor A. A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Rep. 2020 Jan 2;2(1):100064. doi: 10.1016/j.jhepr.2019.100064. PMID: 32039405; PMCID: PMC7005554.

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Mouse CCL24 Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References

Mouse CCL24 Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

Background

References