Human Cannabinoid Receptor 1 VLP Protein

Name: Human Cannabinoid Receptor 1 VLP Protein
Brand: Puweituo Bio
SKU: CB1-HP001

Catalog numberCB1-HP001

HEK293Molecule · CB-RMolecular weight · 52.9 kDa

Product introduction

Recombinant Human Cannabinoid Receptor 1 (CB1) VLP protein is expressed in HEK293 cells and contains Met1-Leu472 (UniProt accession: P21554-1). The full-length receptor is displayed in a virus-like particle format for antibody-binding, immunization and assay-development research.

Product details

Molecular aliases: CB-R; CB R; CBR; CB1; CANN6; CANN6CB1R; Cannabinoid R1; CB1K5; CB1R; CNR; CNR1; SKR6R
Protein length: Met1-Leu472
Expression system: HEK293
Molecular weight: 52.9 kDa
Purity: >95% (HPLC)
Endotoxin: <1 EU/μg (LAL assay)
Formulation: PBS with 300 mM L-arginine, pH 7.4.
Storage: Store at -80°C for up to 12 months. Minimize freeze-thaw cycles.
Negative control: VLP-HM00C

Background

The cannabinoid receptor type 1 (CB1) contributes to gut-brain regulation of appetite and satiety. Peripheral CB1 activation is associated with appetite, energy storage and energy preservation, whereas CB1 antagonism produces opposing effects. This biology has made CB1 a research target in metabolic regulation.

References

1.O'Sullivan SE, Yates AS, Porter RK. The Peripheral Cannabinoid Receptor Type 1 (CB1) as a Molecular Target for Modulating Body Weight in Man. Molecules. 2021 Oct 13;26(20):6178. doi: 10.3390/molecules26206178. PMID: 34684760; PMCID: PMC8538448.

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