Anti-BDCA-2 Antibody (Litifilimab Biosimilar)

Name: Anti-BDCA-2 Antibody (Litifilimab Biosimilar)
Brand: Puweituo Bio
SKU: BDCA2-AB001

Catalog numberBDCA2-AB001

HumanHEK293Molecular weight · 51.68 kDa

Product introduction

Anti-BDCA-2 Antibody (Litifilimab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target BDCA-2, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 51.68 kDa and 23.76 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Litifilimab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Litifilimab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human BDCA-2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Litifilimab Biosimilar with the EC50 of 3.4ng/ml determined by ELISA. (QC Test)

Background

BDCA-2 is a novel type II C-type lectin specifically expressed by plasmacytoid dendritic cells (PDCs) that can internalize antigen for presentation to T cells. Furthermore, signaling via BDCA-2 may play a role in switching from interferon (IFN)-α/β-controlled to interleukin (IL)-12-controlled immune response pathways, as triggering of BDCA-2 potently inhibits secretion of IFN-α/β by PDCs and thereby promotes IL-12 p70 production in PDCs and other cells.

References

1.J Biol Chem. 2015 Jul 3;290(27):16759-71. doi: 10.1074/jbc.M115.660613. Epub 2015 May
2.PMID: 25995448; PMCID: PMC4505424.

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Anti-BDCA-2 Antibody (Litifilimab Biosimilar)

Catalog numberBDCA2-AB001

HumanHEK293Molecular weight · 51.68 kDa

Anti-BDCA-2 Antibody (Litifilimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-BDCA-2 Antibody (Litifilimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References