Human Complement Component C1s Protein

货号PR599101

表达宿主 / 体系: HEK293
种属 (Species): Human
标签: —
纯度 (Purity): > 90% as determined by Bis-Tris PAGE
活性 / 数据: 详询活性数据

代表性质控图

技术参数

种属 (Species)

Human

分子别名 (Synonym)

EDSPD2; C1 esterase;Complement Component C1s

来源/表达系统 (Source)

Recombinant Human Complement C1s Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu16-Asp688 [Accession | P09871].

分子量

The protein has a predicted MW of 75.98 kDa. Due to enzyme lysis glycosylation, the protein migrates to 55-60 kDa (light chain), 32-35 kDa (heavy chain) and 76-96 kDa based on Bis-Tris PAGE result.

内毒素 (Endotoxin)

Less than 1 EU per μg by the LAL method.

纯度 (Purity)

> 90% as determined by Bis-Tris PAGE

制剂 (Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法 (Reconstitution)

Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

存储 (Storage)

-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

文献引用

Subasinghe NL, Khalil E, Travins JM, Ali F, Ballentine SK, Hufnagel HR, Pan W, Leonard K, Bone RF, Soll RM, Crysler CS, Ninan N, Kirkpatrick J, Kolpak MX, Diloreto KA, Eisennagel SH, Huebert ND, Molloy CJ, Tomczuk BE, Gaul MD. Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5303-7. doi: 10.1016/j.bmcl.2012.06.030 Epub 2012 Jun 16. PMID: 22795627.

背景介绍

Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS).

FOLR1-PH1101

人FOLR1蛋白

Human Complement Component C1s Protein

技术参数

文献引用

背景介绍

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Human Complement Component C1s Protein

技术参数

文献引用

背景介绍

相关产品

定制服务与主题入口